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2021 Southern Miss Football Schedule
| Saturday Sep. 4 |  | at South Alabama Jaguars |
| Saturday Sep. 11 |  | Grambling State Tigers |
| Saturday Sep. 18 |  | Troy Trojans |
| Saturday Sep. 25 |  | at Alabama Crimson Tide |
| Saturday Oct. 2 |  | at Rice Owls |
| Saturday Oct. 9 |  | UTEP Miners |
| Saturday Oct. 16 |  | UAB Blazers |
| Saturday Oct. 23 | OFF | |
| Saturday Oct. 30 |  | at Middle Tennessee Blue Raiders |
| Saturday Nov. 6 |  | North Texas Mean Green |
| Saturday Nov. 13 |  | at UTSA Roadrunners |
| Saturday Nov. 20 |  | at Louisiana Tech Bulldogs |
| Saturday Nov. 27 |  | FIU Panthers |
2021 Southern Miss Football Schedule
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Categories: college football schedule
