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2021 Purdue Football Schedule
| Saturday Sep. 4 |  | Oregon State Beavers |
| Saturday Sep. 11 |  | at UConn Huskies |
| Saturday Sep. 18 |  | at Notre Dame Fighting Irish |
| Saturday Sep. 25 |  | Illinois Fighting Illini |
| Saturday Oct. 2 |  | Minnesota Golden Gophers |
| Saturday Oct. 9 |  | at Ohio State Buckeyes |
| Saturday Oct. 16 |  | Nebraska Cornhuskers |
| Saturday Oct. 23 | OFF | |
| Saturday Oct. 30 |  | at Iowa Hawkeyes |
| Saturday Nov. 6 |  | Michigan State Spartans |
| Saturday Nov. 13 |  | at Wisconsin Badgers |
| Saturday Nov. 20 |  | at Northwestern Wildcats |
| Saturday Nov. 27 |  | Indiana Hoosiers |
| Saturday Dec. 4 |  | Big Ten Championship |
2021 Purdue Football Schedule
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