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2021 Michigan State Spartans Football Schedule
| Saturday Sep. 4 |  | at Northwestern Wildcats |
| Saturday Sep. 11 |  | Youngstown State Penguins |
| Saturday Sep. 18 |  | at Miami (FL) Hurricanes |
| Saturday Sep. 25 |  | Nebraska Cornhuskers |
| Saturday Oct. 2 |  | WKU Hilltoppers |
| Saturday Oct. 9 | OFF | |
| Saturday Oct. 16 |  | at Michigan Wolverines |
| Saturday Oct. 23 |  | Penn State Nittany Lions |
| Saturday Oct. 30 |  | at Ohio State Buckeyes |
| Saturday Nov. 6 |  | at Purdue Boilermakers |
| Saturday Nov. 13 |  | Indiana Hoosiers |
| Saturday Nov. 20 |  | at Rutgers Scarlet Knights |
| Saturday Nov. 27 |  | Maryland Terrapins |
| Saturday Dec. 4 |  | Big Ten Championship |
2021 Michigan State Spartans Football Schedule
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Categories: college football schedule
