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2021 LOUISVILLE CARDINALS Football Schedule
| Monday Sep. 6 |  | vs Ole Miss Rebels |
| Saturday Sep. 11 |  | Eastern Kentucky Colonels |
| Friday Sep. 17 |  | UCF Knights |
| Saturday Sep. 25 |  | at Florida State Seminoles |
| Saturday Oct. 2 |  | at Wake Forest Demon Deacons |
| Saturday Oct. 9 |  | Virginia Cavaliers |
| Saturday Oct. 16 | OFF | |
| Saturday Oct. 23 |  | Boston College Eagles |
| Saturday Oct. 30 |  | at NC State Wolfpack |
| Saturday Nov. 6 |  | Clemson Tigers |
| Saturday Nov. 13 |  | Syracuse Orange |
| Thursday Nov. 18 |  | at Duke Blue Devils |
| Saturday Nov. 27 |  | Kentucky Wildcats |
| Saturday Dec. 4 |  | ACC Championship |
2021 LOUISVILLE CARDINALS Football Schedule
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Categories: football
