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2021 LOUISVILLE CARDINALS Football Schedule
| Monday Sep. 6 |  | vs Ole Miss Rebels | BUY TICKETS |
| Saturday Sep. 11 | Eastern Kentucky Colonels | BUY TICKETS | |
| Friday Sep. 17 |  | UCF Knights | BUY TICKETS |
| Saturday Sep. 25 |  | at Florida State Seminoles | BUY TICKETS |
| Saturday Oct. 2 |  | at Wake Forest Demon Deacons | BUY TICKETS |
| Saturday Oct. 9 |  | Virginia Cavaliers | BUY TICKETS |
| Saturday Oct. 16 | OFF | ||
| Saturday Oct. 23 |  | Boston College Eagles | BUY TICKETS |
| Saturday Oct. 30 |  | at NC State Wolfpack | BUY TICKETS |
| Saturday Nov. 6 |  | Clemson Tigers | BUY TICKETS |
| Saturday Nov. 13 |  | Syracuse Orange | BUY TICKETS |
| Thursday Nov. 18 |  | at Duke Blue Devils | BUY TICKETS |
| Saturday Nov. 27 |  | Kentucky Wildcats | BUY TICKETS |
| Saturday Dec. 4 |  | ACC Championship | BUY TICKETS |
2021 LOUISVILLE CARDINALS Football Schedule
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